Dplots Background

Dplots  incorporates a novel methodology of estimating esophageal distension during peristalsis, using saline swallows of a certain conductivity.

To learn more about Dplots and the technical and physiological background behind some of its revolutionary features, see below:

  1. Kim JH, Mittal RK, Patel N, Ledgerwood M, Bhargava V. Esophageal distension during bolus transport: can it be detected by intraluminal impedance recordings? Neurogastroenterol Motil. 2014 Aug;26(8):1122-30. doi: 10.1111/nmo.12369. Epub 2014 May 26. PMID: 24861157; PMCID: PMC4107335.
  2. A. Zifan, M. Ledgerwood, R. K. Mittal, ‘Measurement of Peak Esophageal Luminal Cross-sectional Area Utilizing Nadir Intraluminal Impedance,’ Neurogastroenterology and Motility, 2015 Jul;27(7):971-80. doi: 10.1111/nmo.12571. Epub 2015 Apr 30.
  3. A. Zifan, H. J. Song, Y. H. Youn, X. Qiu, M Ledgerwood-Lee, R.K. Mittal, ‘Topographical plots of esophageal distension and contraction: effects of posture on esophageal peristalsis and bolus transport’. American Journal of Physiology-Gastrointestinal and Liver Physiology, 316(4), G519-G526, 2019.
  4. R.K. Mittal, K. Muta, M. Ledgerwood-Lee, A. Zifan, ‘Relationship Between Distension-Contraction Waveforms during Esophageal Peristalsis: Effect of Bolus Volume, Viscosity and Posture,’ Am J Physiol Gastrointest Liver Physiology;10.1152/ajpgi.00117.2020. doi:10.1152/ajpgi.00117.2020, 2020.
  5. M. Ledgerwood-lee, A. Zifan, W. Lin, J. de Alva, H. Chen, and R.K. Mittal, ‘Novel gel bolus to improve impedance‐based measurements of esophageal cross‐sectional area during primary peristalsis,’ Neurogastroenterology and Motility e14071. https://doi.org/10.1111/nmo.14071, 2020.(Role: Method of analysis, theoretical and intellectual input, manuscript writing, and figure generation).
  6. R.K. Mittal, K Muta, M. Ledgerwood-Lee, V. Gandu, A. Zifan, ‘Abnormal Esophageal Distension Profiles in Patients with Functional Dysphagia: A Possible Mechanism of Dysphagia,’ Gastroenterology, Volume 160, Issue 5, Pages 1847-1849.e2, ISSN 0016-5085, https://doi.org/10.1053/j.gastro.2020.12.002, 2021.
  7. A. Zifan, K. Muta, and R.K. Mittal, ‘Distension‐contraction profile of peristalsis in patients with nutcracker esophagus,’ Neurogastroenterology & Motility e14138. https://doi.org/10.1111/nmo.14138, 2021.
  8. A Zifan , V Gandu V, M Ledgerwood, RK Mittal, ‘Bolus flow and biomechanical properties of the esophageal wall during primary esophageal peristalsis: Effects of bolus viscosity and posture,’ Neurogastroenterology & Motility. 2021 Oct 11:e14281.
  9. K Muta, RK Mittal, A Zifan, PloS one, ‘Rhythmic contraction but arrhythmic distension of esophageal peristaltic reflex in patients with dysphagia,’ 2022, Vol.17(1), p.e0262948
  10. 2. T. Omari, A. Zifan, C. Cock, and R.K. Mittal, ‘Distension contraction plots of pharyngeal/esophageal peristalsis: next frontier in the assessment of esophageal motor function,’ American Journal of Physiology-Gastrointestinal and Liver Physiology 2022, 323:3, G145-G156.
  11. A Zifan, V. Gandu, and R. K. Mittal, ‘Esophageal wall compliance/stiffness during peristalsis in patients with functional dysphagia and high-amplitude esophageal contractions’, American Journal of Physiology-Gastrointestinal and Liver Physiology 2022 323:6, G586-G593.
  12. Muta, K., R K Mittal, A Zifan., 413 Distension contraction plots of esophageal peristalsis generated using an automated computer program. Gastroenterology, 2020. 158(6): p. S-79-S-80